Morphological and molecular basis of ovarian serous carcinoma
نویسندگان
چکیده
Serous carcinoma is the most common type of epithelial ovarian cancer. In this review, we provide a comprehensive picture of ovarian serous cancers from multiple aspects: the first part of this review summarizes the morphological, histological, and immunological signatures of ovarian serous carcinoma; subsequently, we review the history of the evolvement of different grading systems used in ovarian serous cancer; in the end, we focus on characterizing the genetics that underlie the 2-tiered pathways through which ovarian serous cancers are believed to arise: the low-grade and the high-grade pathways.
منابع مشابه
طبقهبندی مجدد کارسینوماهای سروز تخمدان با روش جدید تقسیمبندی دوگانه (two-tier) و بررسی بروز ژن P53 با رنگآمیزی ایمونوهیستوشیمی
Background: Recently the use of “two tier" grading system in which ovarian serous carcinoma was classified as low-grade or high-grade in comparing to preceding system has improved authority in prognosis and survival. This approach is simplistic, reproducible, and based on biologic evidence. In this study, we reclassified ovarian serous carcinoma by a new two-tier system for grading and then eva...
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